Quantitative assessment of the association between AXIN2 rs2240308 polymorphism and cancer risk
نویسندگان
چکیده
منابع مشابه
Quantitative assessment of the association between AXIN2 rs2240308 polymorphism and cancer risk
Axin2 is involved in the regulation of Wnt/β-catenin pathway and implicated in cancer development and progression. The association between AXIN2 rs2240308 polymorphism and cancer risk has been examined in several case-control studies, but the conclusions were conflicting. Here we performed a meta-analysis to evaluate the role of rs2240308 in cancer risk. A total of 8 studies were included in th...
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The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single nucleotide polymorphism (SNP) rs2240308 [guanine (G)/adenine (A)] and the inc...
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Accumulated evidence suggests that alterations due to mutations or genetic polymorphisms in the AXIN2 tumor suppressor gene, a component of the Wnt signaling pathway, contributes to carcinogenesis. The effect of the AXIN2 exon 1 148 C↷T polymorphism was recently investigated in a Japanese population, but has not been investigated in other populations. Additionally, other common polymorphisms of...
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PURPOSE The association between GNB3 C825T polymorphism and cancer risk has been investigated. However, results remain inconclusive. In this study we aimed to obtain a more precise estimation of this association. METHODS A meta-analysis of 8 eligible studies including 1,812 cancer cases and 3,731 controls was conducted with odds ratios (ORs) and the corresponding 95% confidence interval (95% ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep10111